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121 Center Rd
From Points North
Take I-290 to Auburn, where it connects with I-395 South. Follow I-395 to Exit 4B (Sutton Road/Oxford Center). Turn right off ramp and stay in the right lane. Go straight through the light at Oxford center. Follow straight for 0.8 miles and take a left onto Dudley Road. Follow this road for 3.7 miles, staying straight through a four-way stop sign. Dudley Road becomes Dudley/Oxford Road at the town line. As the road forks, bear right to continue on Dudley/Oxford Road for 2 miles through two stop signs, then straight onto the Nichols campus.
From Points East & West
Take the Mass Pike to Exit 10 in Auburn. Follow signs for I-395 South, and continue directions above.
From Points South
Take I-95 North to I-395 North to Exit 2 (Webster) and turn left off the ramp. After the first set of traffic lights, continue to follow Route 12 South through Webster center, where it will turn left. Continue through Webster center. After the railroad tracks, continue straight into Dudley. At the intersection with Schofield Avenue, Route 12 will bear left. You will stay straight onto Route 197/Main Street. Continue straight until you reach a set of lights near a Cumberland Farms convenience store. Turn right directly after onto Airport Rd. Follow Airport Road and bear right at the Webster-Dudley Golf Course. Take the first left onto Center Road and proceed directly onto the Nichols campus.
From Hartford, CT
Take I-84 East towards Boston. Take Exit 2 (Sturbridge/Southbridge). On the exit ramp, keep right at the fork. Turn left onto Haynes Street. Turn right onto Route 131/Main Street. Continue to the rotary in Southbridge and take the first right onto Route 169/131. You will pass through Dudley, Massachusetts, then enter Thompson, Connecticut, for a short while. Turn left onto Route 197 in Thompson. You will re-enter Dudley on Route 197. Turn left onto Center Road. Follow Center Road up the hill to the Nichols campus.